The relationship between man and nature is the essential one in the interactive relationships of human society. The idea of harmonious coexistence between man and nature is the scientific direction to promote the construction of ecological civilization in the new era. Against the background of current trends in social development such as knowledge progress, technological iteration, and institutional change, and with the deepening of human understanding of the relationship between man and nature, it is necessary to reconstruct the harmonious symbiotic relationship between man and nature based on the multi-dimensional connection of "culture-technology-power-system". Therefore, we need to re-examine the relationship between man and nature, expound the contemporary meaning of the relationship between man and nature from different dimensions, and create a multi-dimensional integrated path of harmonious coexistence between man and nature in the new era, and these measures are of great practical significance for promoting harmonious coexistence between man and nature and achieving high-quality economic development.